At SKUAST-K, scientists use bio-technology to research on cancer treatment

Last year, a study titled “Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia” was published in Journal of Endocrinology. The study has 16 authors with Laura E Pascal, June Liu and Khalid Z Masoodi as leading authors.

ZEHRU NISSA
Srinagar, Publish Date: Feb 22 2018 12:20AM | Updated Date: Feb 22 2018 12:20AM
At SKUAST-K, scientists use bio-technology to research on cancer treatmentRepresentational Pic

Researchers at Sher-e-Kashmir University of Agriculture Sciences and Technology-Kashmir (SKUAST-K), in collaboration with leading organizations around the world, have taken up studies aimed at reducing the incidence of different cancers and finding treatment to the deadly disease.

Recently a study on role of DHX15 - a newly discovered gene that “drives the spread and growth of cancerous cells” was published in Oncogene, a journal published by Nature group. The study has been carried out by a team of 14 scientists led by Dr Y Jing from Pittsburg University. One of the scientists in the team, Dr Khalid Z Masoodi is from SKAUST Kashmir. The research, as per SKAUST, is the first study to reveal how DHX15 expression is associated with prostate cancer recurrence and provides a potential new molecular target for the treatment of advanced prostate cancer.

This, however, is not the only study related to prostate cancer where SKAUST has collaborated. Last year, a study titled “Conditional deletion of ELL2 induces murine prostate intraepithelial neoplasia” was published in Journal of Endocrinology. The study has 16 authors with Laura E Pascal, June Liu and Khalid Z Masoodi as leading authors.

Earlier, a study titled “Inhibition of Androgen Receptor Nuclear Localization and Castration Resistant Prostate Tumor Growth by Pyrroloimidazole-Based Small Molecules” was published in Molecular Cancer Therapeutics. The Pittsburgh University project was carried out at different universities including SKAUST-K with a scientist from the University as its lead author. 

Vice Chancellor SKAUST, Dr Nazeer Ahmed, while speaking to Greater Kashmir said that in the past few years, the university has been actively integrating bio-technology and other sciences with research on cancers. “Our aim is to help people have a better quality of life. We are working on a number of studies in this direction,” he said.

He said that the university has been able to extrapolate the studies done at University of Pittsburgh. “Our researchers, together with best of the minds in other universities, have been able to discover three new small molecule inhibitors against prostate cancer, tested on cell lines and mice xenograft prostate cancer tumours,” he said.

“Reducing the cancer burden is one of the key areas, and we are working on projects that could help devise molecules, technologies and steer findings that could not only help in treatment of the deadly disease but also bring down the incidence,” he said.

Dr Ahmed said that currently, the university was working on a project that may help reduce the use of pesticides. “The overuse of pesticides has strong links to a variety of cancers here. Reduction in use of pesticides might help bring down a number of cancers that have been seen to be afflicting the farming community mostly,” he said.

The university has a Rs 2 crore funding from Science and Engineering Research Board of department of science and technology, government of India and ministry of AYUSH, focused on drug discovery from medicinal plants endogenous to J&K state.

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